Article
The spectrum of TP53 mutations in bladder carcinoma.
Genes, chromosomes & cancer - 1 Feb 1994
Williamson M P, Elder P A, Knowles M A
Abstract excerpt
The mutational spectrum for the TP53 gene was investigated in a large series of bladder tumors and bladder tumor cell lines. Tumors and cell lines were screened for the presence of TP53 point mutations by single-strand conformational polymorphism analysis followed by direct sequencing. Mutations were detected in 16 of 88 (18%) tumors and 4 of 14 cell lines (28%). In total, twelve missense mutations, one nonsense...
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