Article
The spectrum of TP53 mutations in bladder carcinoma.
Genes, chromosomes & cancer - 1 Feb 1994
Williamson M P, Elder P A, Knowles M A
Abstract excerpt
The mutational spectrum for the TP53 gene was investigated in a large series of bladder tumors and bladder tumor cell lines. Tumors and cell lines were screened for the presence of TP53 point mutations by single-strand conformational polymorphism analysis followed by direct sequencing. Mutations...
Topics
- Alleles
- Base Sequence
- Blotting, Southern
- Carcinoma
- Chromosome Aberrations
- Chromosomes, Human, Pair 17
- Codon
- DNA Mutational Analysis
- DNA, Neoplasm
- Exons
- Genes, p53
- Heterozygote
- Humans
- Molecular Sequence Data
- Point Mutation
- Polymerase Chain Reaction
- Polymorphism, Genetic
- Repetitive Sequences, Nucleic Acid