Article
Computer program for the analysis of mutational spectra: application to p53 mutations.
Carcinogenesis - 1 Oct 1994
Cariello N F, Piegorsch W W, Adams W T, Skopek T R
Abstract excerpt
Mutations in the p53 oncogene are extremely common in human cancers, and environmental exposure to mutagenic agents may play a role in the frequency and nature of the mutations. Differences in the patterns of p53 mutations have been observed for different tumor types. It is not trivial to determine if the differences observed in two mutational spectra are statistically significant. To this end, we present a...
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