Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers.

Cancer research - 15 Jun 2005

Le Calvez Florence, Mukeria Anush, Hunt Jay D, Kelm Olaf, Hung Rayjean J, Tanière Philippe, Brennan Paul, Boffetta Paolo, Zaridze David G, Hainaut Pierre

Abstract excerpt

TP53 mutations are common in lung cancers of smokers, with high prevalence of G:C-to-T:A transversions generally interpreted as mutagen fingerprints of tobacco smoke. In this study, TP53 (exons 5-9) and KRAS (codon 12) were analyzed in primary lung tumors of never (n = 40), former (n = 27), and current smokers (n = 64; mainly heavy smokers). Expression of p53, cyclooxygenase-2 (Cox-2), and nitrotyrosine (N-Tyr),...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cyclooxygenase 2
Share to Genes, p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genes, ras

Share to Immunohistochemistry

Share to Prostaglandin-Endoperoxide Synthases

Share to Smoking

Share to Tumor Suppressor Protein p53

Share to Tyrosine

Source

Identifiers

PMID: 15958551
DOI: 10.1158/0008-5472.CAN-05-0551

Genes

KRAS

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TP53 and KRAS mutation load and types in lung cancers in relation to tobacco smoke: distinct patterns in never, former, and current smokers.PMID 15958551Read ↗

TP53 Mutation Spectrum in Smokers and Never Smoking Lung Cancer PatientsSemantic proximity Read ↗

Frequency and distinctive spectrum of KRAS mutations in never smokers with lung adenocarcinoma.Semantic proximity Read ↗

Smoking, p53 mutation, and lung cancer.Semantic proximity Read ↗

Lung tumor KRAS and TP53 mutations in nonsmokers reflect exposure to PAH-rich coal combustion emissions.Semantic proximity Read ↗

p53 mutations in non-small-cell lung cancers occurring in individuals without a past history of active smoking.Semantic proximity Read ↗

p53 and K-ras mutations in lung cancers from former and never-smoking women.Semantic proximity Read ↗

Prevalence and spectrum of p53 mutations associated with smoking in breast cancer.Semantic proximity Read ↗

Tobacco smoke carcinogens, DNA damage and p53 mutations in smoking-associated cancers.Semantic proximity Read ↗

TP53 mutation spectrum in lung cancers and mutagenic signature of components of tobacco smoke: lessons from the IARC TP53 mutation databaseSemantic proximity Read ↗

The TP53 gene, tobacco exposure, and lung cancer.Semantic proximity Read ↗

Higher TP53 somatic mutation prevalence from liquid biopsy analysis in ever smoker non-small-cell lung cancer patients.Semantic proximity Read ↗

Molecular epidemiology of EGFR and KRAS mutations in 3,026 lung adenocarcinomas: higher susceptibility of women to smoking-related KRAS-mutant cancers.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.