Article
Alterations of the p53 gene in occupational bladder cancer in workers exposed to aromatic amines.
Laboratory investigation; a journal of technical methods and pathology - 1 Dec 1997
Yasunaga Y, Nakanishi H, Naka N, Miki T, Tsujimura T, Itatani H, Okuyama A, Aozasa K
Abstract excerpt
Epidemiologic studies have revealed an increased risk for development of transitional cell carcinoma (TCC) among dye workers/painters occupationally exposed to aromatic amines such as benzidine, beta-naphthylamine, orthotoluidine, and aniline. In the present study, p53 gene mutations in 26 patients with bladder lesions occupationally exposed to aromatic amines were examined by single-strand conformation...
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