Article
TP53 alterations and patterns of carcinogen exposure in a U.S. population-based study of bladder cancer.
International journal of cancer - 10 Nov 2005
Kelsey Karl T, Hirao Tomoko, Hirao Shuya, Devi-Ashok Tara, Nelson Heather H, Andrew Angeline, Colt Joanne, Baris Dalsu, Morris J Steven, Schned Alan, Karagas Margaret
Abstract excerpt
The molecular pathology of bladder cancer has been the subject of considerable interest, and current efforts are targeted toward elucidating the interrelationships between individual somatic gene loss and both etiologic and prognostic factors. Mutation of the TP53 gene has been associated with more invasive bladder cancer, and evidence suggests that TP53 mutation, independent of stage, may be predictive of...
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