Article
P53 alterations in bladder tumors from arsenic and tobacco exposed patients.
Carcinogenesis - 1 Nov 2003
Moore Lee E, Smith Allan H, Eng Clarence, DeVries Sandy, Kalman Dave, Bhargava Vivek, Chew Karen, Ferreccio Catterina, Rey Omar A, Hopenhayn Claudia, Biggs Mary Lou, Bates Michael N, Waldman Frederic M
Abstract excerpt
Previous studies demonstrated that tobacco and arsenic exposure are risk factors for bladder cancer. A case-case study was conducted to compare p53 mutations in 147 bladder tumors from South American patients by tobacco and arsenic exposure. Information on residential history and lifestyle factors was collected. The prevalence of p53 mutations and protein expression was examined in relation to tumor stage, grade,...
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