Article
Conservation of binding site geometry among p-azophenylarsonate-specific antibodies.
Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1993
Parhami-Seren B, Kussie P H, Strong R K, Margolies M N
Abstract excerpt
Murine A/J anti-p-azophenylarsonate mAb that express a dominant cross-reactive Id are encoded by a single set of germ-line VH and VL region genes. The crystal structure of the Fab of antibody 36-71, which uses this canonical set of genes but is somatically mutated, was previously determined. An F...
Topics
- Amino Acid Sequence
- Antibody Affinity
- Base Sequence
- Binding Sites, Antibody
- Humans
- Immunoglobulin Idiotypes
- Models, Molecular
- Molecular Sequence Data
- Mutation
- Radioimmunoassay
- Structure-Activity Relationship
- p-Azobenzenearsonate