Verification of a model of a F(ab) complex with phenylarsonate by oligonucleotide-directed mutagenesis.

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Article

Verification of a model of a F(ab) complex with phenylarsonate by oligonucleotide-directed mutagenesis.

Journal of immunology (Baltimore, Md. : 1950) - 1 Mar 1993

Sompuram S R, Sharon J

Abstract excerpt

A model of the combining site of a mouse antibody specific for p-azophenylarsonate was tested by oligonucleotide-directed mutagenesis of the proposed hapten-contacting residues, Arg96 in the L chain, and Asn35, Trp47, Tyr50, Ser95, and Tyr100b in the H chain. The affinity and relative affinity fo...

Topics

Antibody Affinity
Arsenicals
Base Sequence
Binding Sites, Antibody
Enzyme-Linked Immunosorbent Assay
Immunoglobulin Fab Fragments
Molecular Sequence Data
Mutagenesis, Site-Directed
Mutation
Structure-Activity Relationship

Source

Open in PubMed

Identifiers

PMID: 8436817

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8436817-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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