Article
Immunological origins of binding and catalysis in a Diels-Alderase antibody.
Science (New York, N.Y.) - 20 Mar 1998
Romesberg F E, Spiller B, Schultz P G, Stevens R C
Abstract excerpt
The three-dimensional structure of an antibody (39-A11) that catalyzes a Diels-Alder reaction has been determined. The structure suggests that the antibody catalyzes this pericyclic reaction through a combination of packing and hydrogen-bonding interactions that control the relative geometries of...
Topics
- Amino Acid Sequence
- Antibodies
- Antibodies, Catalytic
- Antibody Affinity
- Antibody Specificity
- Binding Sites
- Binding Sites, Antibody
- Catalysis
- Chemistry, Organic
- Cloning, Molecular
- Crystallography, X-Ray
- Evolution, Molecular
- Germ-Line Mutation
- Haptens
- Hydrogen Bonding
- Immunoglobulin Fab Fragments
- Models, Molecular
- Molecular Sequence Data