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Article

Immunological origins of binding and catalysis in a Diels-Alderase antibody.

Science (New York, N.Y.) - 20 Mar 1998

Romesberg F E, Spiller B, Schultz P G, Stevens R C

Abstract excerpt

The three-dimensional structure of an antibody (39-A11) that catalyzes a Diels-Alder reaction has been determined. The structure suggests that the antibody catalyzes this pericyclic reaction through a combination of packing and hydrogen-bonding interactions that control the relative geometries of the bound substrates and electronic distribution in the dienophile. A single somatic mutation, serine-91 of the light...

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Identifiers

PMID: 9506942
DOI: 10.1126/science.279.5358.1929

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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