Article
Crystal structure of an Fv-Fv idiotope-anti-idiotope complex at 1.9 A resolution.
Journal of molecular biology - 22 Nov 1996
Braden B C, Fields B A, Ysern X, Dall'Acqua W, Goldbaum F A, Poljak R J, Mariuzza R A
Abstract excerpt
Anti-idiotopic antibodies react with unique antigenic features, usually associated with the combining sites, of other antibodies. They may thus mimic specific antigens that react with the same antibodies. The structural basis of this mimicry is analyzed here in detail for an anti-idiotopic antibo...
Topics
- Animals
- Antibodies, Anti-Idiotypic
- Antigen-Antibody Complex
- Chickens
- Crystallography, X-Ray
- Female
- Hydrogen Bonding
- Immunoglobulin Fragments
- Immunoglobulin Idiotypes
- Mice
- Models, Molecular
- Molecular Mimicry
- Molecular Structure
- Muramidase
- Mutation
- Protein Conformation
- Surface Properties