Article
Post-translational modifications of the env-sea oncogene product: the role of proteolytic processing in transformation.
Oncogene - 1 Jan 1993
Crowe A J, Hayman M J
Abstract excerpt
The transforming gene product of the S13 avian erythroblastosis virus, env-sea, is a member of the growth factor receptor class of tyrosine kinases. The env-sea precursor protein gp155env-sea is proteolytically processed into the mature cleavage products gp85env-sea and gp70env-sea which are subsequently terminally glycosylated. Previous studies have shown that the abnormal glycosylation of gp155env-sea which...
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