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Article

Effects of retroviral envelope-protein cleavage upon trafficking, incorporation, and membrane fusion.

Virology - 15 Sept 2010

Apte Swapna, Sanders David Avram

Abstract excerpt

Retroviral envelope glycoproteins undergo proteolytic processing by cellular subtilisin-like proprotein convertases at a polybasic amino-acid site in order to produce the two functional subunits, SU and TM. Most previous studies have indicated that envelope-protein cleavage is required for rendering the protein competent for promoting membrane fusion and for virus infectivity. We have investigated the role of...

Topics

Amino Acid Substitution
Animals
Humans
Mice
Moloney murine leukemia virus
Mutation
NIH 3T3 Cells
Protein Transport
Viral Envelope Proteins
Virus Attachment
Virus Internalization

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 20591459
DOI: 10.1016/j.virol.2010.06.004

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