Proteolytic cleavage at the Gag-Pol junction in avian leukosis virus: differences in vitro and in vivo.

doi:10.1006/viro.1994.1509

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Article

Proteolytic cleavage at the Gag-Pol junction in avian leukosis virus: differences in vitro and in vivo.

Virology - 1 Oct 1994

Stewart L, Vogt V M

Abstract excerpt

In avian leukosis virus, processing by the viral protease (PR) appears to activate reverse transcriptase (RT), since PR-defective virions have extremely feeble reverse transcriptase activity. We showed previously that when such detergent-treated virions are digested in vitro with PR, the Gag precursor is completely and properly matured, but the Gag-Pol precursor is not. In particular, the junction between Gag and...

Topics

Amino Acid Sequence
Avian Leukosis Virus
Baculoviridae
Base Sequence
Cell Line
Endopeptidases
Fusion Proteins, gag-pol
Leucine Zippers
Models, Biological
Molecular Sequence Data
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Protein Conformation

Protein Processing, Post-Translational

RNA-Directed DNA Polymerase

Recombinant Proteins

Viral Proteins

Virion

Source

Open in PubMed

Identifiers

PMID: 7522375
DOI: 10.1006/viro.1994.1509

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7522375-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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