Article
The v-ski oncogene cooperates with the v-sea oncogene in erythroid transformation by blocking erythroid differentiation.
Oncogene - 1 Oct 1992
Larsen J, Beug H, Hayman M J
Abstract excerpt
The avian retrovirus oncogene v-ski was analysed for its ability to alter the differentiation program of erythroid cells and to cooperate with tyrosine kinase oncogenes in leukemogenesis. For this, a retrovirus combining v-ski with a temperature-sensitive version of the v-sea oncogene was constructed. In transformed erythroblasts, v-ski disturbed the concerted expression of several erythrocyte genes, leading to...
Topics
- Animals
- Cell Differentiation
- Cell Transformation, Neoplastic
- Chick Embryo
- Erythroblasts
- Gene Expression
- Leukemia, Experimental
- Oncogene Proteins, Viral
- Oncogenes
- Phenotype
- Protein-Tyrosine Kinases