Article
Processing of avian retroviral gag polyprotein precursors is blocked by a mutation at the NC-PR cleavage site.
Journal of virology - 1 Mar 1992
Burstein H, Bizub D, Kotler M, Schatz G, Vogt V M, Skalka A M
Abstract excerpt
The avian sarcoma and leukosis viruses (ASLV) encode a protease (PR) at the C terminus of gag which in vivo catalyzes the processing of both gag and gag-pol precursors. The studies reported here were undertaken to determine whether PR is able to cleave these polyproteins while it is still part of...
Topics
- Amino Acid Sequence
- Animals
- Avian Sarcoma Viruses
- Cell Line
- Chlorocebus aethiops
- Gene Products, gag
- Gene Products, pol
- In Vitro Techniques
- Molecular Sequence Data
- Mutation
- Protein Precursors
- Protein Processing, Post-Translational
- Proteins