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Article

Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein.

Oncogene - 3 Feb 2000

Epinat J C, Kazandjian D, Harkness D D, Petros S, Dave J, White D W, Gilmore T D

Abstract excerpt

The retroviral oncoprotein v-Rel is a member of the Rel/ NF-kappaB family of transcription factors. v-Rel has multiple changes as compared to the proto-oncoprotein c-Rel, and these changes render v-Rel highly oncogenic in avian lymphoid cells. Previous results have shown that three mutant residues in the eleven helper virus-derived Envelope (Env) amino acids (aa) at the N-terminus of v-Rel are required for its...

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PMID: 10698504
DOI: 10.1038/sj.onc.1203376

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutant envelope residues confer a transactivation function onto N-terminal sequences of the v-Rel oncoprotein.PMID 10698504Read ↗

The N-terminal env-derived amino acids of v-rel are required for full transforming activity.Semantic proximity Read ↗

Differences in kappaB DNA-binding properties of v-Rel and c-Rel are the result of oncogenic mutations in three distinct functional regions of the Rel protein.Semantic proximity Read ↗

Transformation by the vRel oncoprotein requires sequences carboxy-terminal to the Rel homology domain.Semantic proximity Read ↗

Multiple mutations contribute to the oncogenicity of the retroviral oncoprotein v-Rel.Semantic proximity Read ↗

Discreet mutations from c-Rel to v-Rel alter kappaB DNA recognition, IkappaBalpha binding, and dimerization: implications for v-Rel oncogenicity.Semantic proximity Read ↗

ERK and JNK activation is essential for oncogenic transformation by v-Rel.Semantic proximity Read ↗

Three mutations in v-Rel render it resistant to cleavage by cell-death protease caspase-3.Semantic proximity Read ↗

Mutations in the DNA-binding and dimerization domains of v-Rel are responsible for altered kappa B DNA-binding complexes in transformed cells.Semantic proximity Read ↗

Malignant transformation by mutant Rel proteins.Semantic proximity Read ↗

In vivo evolution of c-rel oncogenic potential.Semantic proximity Read ↗

A protein kinase-A recognition sequence is structurally linked to transformation by p59v-rel and cytoplasmic retention of p68c-rel.Semantic proximity Read ↗

Mutational analysis of the role of the carboxy-terminal region of the v-erbB protein in erythroid cell transformation.Semantic proximity Read ↗

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