Article
Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.
Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1993
Hino O, Klein-Szanto A J, Freed J J, Testa J R, Brown D Q, Vilensky M, Yeung R S, Tartof K D, Knudson A G
Abstract excerpt
Hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. At the histologic level, RCs develop through multiple stages from early preneoplastic lesions (e.g., atypical tu...
Topics
- Adenoma
- Animals
- Carcinoma, Renal Cell
- Cesium Radioisotopes
- Chromosome Aberrations
- Chromosome Disorders
- Chromosome Mapping
- Chromosomes, Human
- Crosses, Genetic
- Embryonic and Fetal Development
- Female
- Gamma Rays
- Gene Deletion
- Genes, Dominant