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Article

Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.

Proceedings of the National Academy of Sciences of the United States of America - 1 Jan 1993

Hino O, Klein-Szanto A J, Freed J J, Testa J R, Brown D Q, Vilensky M, Yeung R S, Tartof K D, Knudson A G

Abstract excerpt

Hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. At the histologic level, RCs develop through multiple stages from early preneoplastic lesions (e.g., atypical tubules) to adenomas in virtually all heterozygotes by the age of 1 year. The homozygous mutant condition is lethal at...

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Identifiers

PMID: 8419937
DOI: 10.1073/pnas.90.1.327
PMCID: PMC45653

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Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.PMID 8419937Read ↗

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