Article
Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2).
Molecular carcinogenesis - 1 Sept 1995
Hino O, Kobayashi E, Hirayama Y, Kobayashi T, Kubo Y, Tsuchiya H, Kikuchi Y, Mitani H
Abstract excerpt
We have recently identified on rat chromosome 10q a germline mutation in the tuberous sclerosis gene (Tsc2), the gene predisposing to renal carcinoma (RC) in the Eker rat. The homozygous mutant condition is lethal at around the 13th day of fetal life. In heterozygotes, RCs invariably develop in the first year of life. Histologically, RCs develop through multiple stages from early preneoplastic lesions (i.e.,...
Topics
- Amino Acid Sequence
- Animals
- Base Sequence
- Carcinoma, Renal Cell
- Carrier Proteins
- Cell Cycle Proteins
- Cell Line
- Chromosome Deletion
- Chromosome Mapping
- Cyclin-Dependent Kinase Inhibitor p15