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Article

Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome.

The Journal of urology - 1 Dec 1992

Everitt J I, Goldsworthy T L, Wolf D C, Walker C L

Abstract excerpt

A rodent model of hereditary cancer in which a single gene mutation predisposes rats to bilateral multicentric renal cell carcinoma (RCC) is described. This rat hereditary cancer syndrome shares certain similarities with von Hippel-Lindau disease (VHLD). In addition to the early development of renal epithelial tumors with morphologic similarity to human RCC, rats which bear the RCC gene are predisposed to the...

Topics

Animals
Carcinoma, Renal Cell
Female
Kidney Neoplasms
Male
Mutation
Rats
Rats, Mutant Strains
Syndrome
Time Factors

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 1433648
DOI: 10.1016/s0022-5347(17)37087-8

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1433648-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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