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Article

Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome.

The Journal of urology - 1 Dec 1992

Everitt J I, Goldsworthy T L, Wolf D C, Walker C L

Abstract excerpt

A rodent model of hereditary cancer in which a single gene mutation predisposes rats to bilateral multicentric renal cell carcinoma (RCC) is described. This rat hereditary cancer syndrome shares certain similarities with von Hippel-Lindau disease (VHLD). In addition to the early development of renal epithelial tumors with morphologic similarity to human RCC, rats which bear the RCC gene are predisposed to the...

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PMID: 1433648
DOI: 10.1016/s0022-5347(17)37087-8

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Hereditary renal cell carcinoma in the Eker rat: a rodent familial cancer syndrome.PMID 1433648Read ↗

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Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.Semantic proximity Read ↗

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Use of the spontaneous Tsc2 knockout (Eker) rat model of hereditary renal cell carcinoma for the study of renal carcinogens.Semantic proximity Read ↗

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Hereditary renal carcinogenesis fitting Knudson's two-hit model: genotype, environment, and phenotype.Semantic proximity Read ↗

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