Increased susceptibility to in vitro transformation of cells carrying the Eker tumor susceptibility mutation.

doi:10.1093/carcin/15.10.2183

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Article

Increased susceptibility to in vitro transformation of cells carrying the Eker tumor susceptibility mutation.

Carcinogenesis - 1 Oct 1994

Horesovsky G, Ginsler J, Everitt J, Walker C

Abstract excerpt

Rats carrying the Eker tumor susceptibility mutation are genetically predisposed to renal cell carcinoma. Rats heterozygous for the Eker mutation (Eker carriers) develop multiple bilateral renal cell carcinomas by the age of 1 year. Using an in vitro rat kidney epithelial (RKE) transformation ass...

Topics

Animals
Carcinoma, Renal Cell
Cell Transformation, Neoplastic
Cocarcinogenesis
Epithelial Cells
Epithelium
Female
Kidney Neoplasms
Kidney Tubules
Male
Methylnitronitrosoguanidine
Mutation
Rats
Rats, Mutant Strains

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