Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

doi:10.1073/pnas.91.24.11413

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Article

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.

Proceedings of the National Academy of Sciences of the United States of America - 22 Nov 1994

Yeung R S, Xiao G H, Jin F, Lee W C, Testa J R, Knudson A G

Abstract excerpt

Genetic predisposition to neoplasia often involves tumor suppressor genes. One such model of hereditary renal carcinoma was described in the rat by Eker. These tumors share morphologic similarities with human renal cancer. Linkage analysis localized the inherited mutation to rat chromosome band 1...

Topics

Animals
Base Sequence
Carcinoma
Chromosomes, Human, Pair 16
DNA Primers
Gene Expression
Gene Rearrangement
Genes, Tumor Suppressor
Genetic Linkage
Humans
Kidney Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Molecular Sequence Data

Mutation

RNA, Messenger

Rats

Rats, Mutant Strains

Repressor Proteins

Tissue Distribution

Source

Open in PubMed Open full text

Identifiers

PMID: 7972075
DOI: 10.1073/pnas.91.24.11413
PMCID: PMC45241

Genes

TSC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7972075-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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