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Article

Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat.

Cancer research - 15 May 1994

Kubo Y, Mitani H, Hino O

Abstract excerpt

Hereditary renal carcinoma (RC) in the rat, originally reported by Eker in 1954, is an example of a Mendelian dominant predisposition to a specific cancer in an experimental animal. We previously reported that ionizing radiation induces additional tumors in a linear dose-response relationship, suggesting that in heterozygotes two events (one inherited, one somatic) are necessary to produce tumors. Recently, the...

Topics

Alleles
Animals
Base Sequence
Carcinoma, Renal Cell
Ethylnitrosourea
Female
Gene Deletion
Genes, Tumor Suppressor
Heterozygote
Kidney Neoplasms
Male
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Rats

Source

Identifiers

PMID: 8168090

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-8168090-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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