Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure.

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Back to search

Article

Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure.

Cancer research - 1 Mar 1995

Kubo Y, Klimek F, Kikuchi Y, Bannasch P, Hino O

Abstract excerpt

Hereditary renal cell carcinomas invariably develop by the age of 1 year in Eker rats. At the histological level, renal cell carcinomas develop through multiple stages from early preneoplastic lesions (e.g., phenotypically altered tubules) to adenomas. We previously reported that ionizing radiation induces additional tumors (large adenomas and carcinomas) in a linear dose-response relationship and that loss of...

Topics

Animals
Base Sequence
Carcinoma, Renal Cell
Chromosomes
Dissection
Female
Gene Deletion
Heterozygote
Kidney Neoplasms
Kidney Tubules
Laser Therapy
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Microsurgery

Molecular Sequence Data

Mutation

Phenotype

Precancerous Conditions

Rats

Source

Open in PubMed

Identifiers

PMID: 7867009

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-7867009-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Early detection of Knudson's two-hits in preneoplastic renal cells of the Eker rat model by the laser microdissection procedure.PMID 7867009Read ↗

Allelic loss at the tuberous sclerosis (Tsc2) gene locus in spontaneous uterine leiomyosarcomas and pituitary adenomas in the Eker rat model.Semantic proximity Read ↗

Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation-associated renal tumors in Eker rats.Semantic proximity Read ↗

Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2).Semantic proximity Read ↗

Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.Semantic proximity Read ↗

Intragenic Tsc2 somatic mutations as Knudson's second hit in spontaneous and chemically induced renal carcinomas in the Eker rat model.Semantic proximity Read ↗

Renal carcinogenesis: genotype, phenotype and dramatype.Semantic proximity Read ↗

Allelic loss at the tuberous sclerosis 2 locus in spontaneous tumors in the Eker rat.Semantic proximity Read ↗

Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat.Semantic proximity Read ↗

Estrogen treatment enhances hereditary renal tumor development in Eker rats.Semantic proximity Read ↗

Use of the spontaneous Tsc2 knockout (Eker) rat model of hereditary renal cell carcinoma for the study of renal carcinogens.Semantic proximity Read ↗

The Genetic Basis of Kidney Cancer: Why is Tuberous Sclerosis Complex Often Overlooked?Semantic proximity Read ↗

Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.