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Article

Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells.

Biochemical and biophysical research communications - 6 Feb 1996

Orimoto K, Tsuchiya H, Kobayashi T, Matsuda T, Hino O

Abstract excerpt

The hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an excellent example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Recently, we have identified a germline mutation of the sclerosis (Tsc2) gene in the Eker rat (Nature Genetics 9, 70-74, 1995), suggested to be a novel tumor suppressor gene, fitting Knudson's two-hit...

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PMID: 8619830
DOI: 10.1006/bbrc.1996.0183

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