Article
Suppression of the neoplastic phenotype by replacement of the Tsc2 gene in Eker rat renal carcinoma cells.
Biochemical and biophysical research communications - 6 Feb 1996
Orimoto K, Tsuchiya H, Kobayashi T, Matsuda T, Hino O
Abstract excerpt
The hereditary renal carcinoma (RC) in the rat, originally reported by R. Eker in 1954, is an excellent example of a Mendelian dominantly inherited predisposition to a specific cancer in an experimental animal. Recently, we have identified a germline mutation of the sclerosis (Tsc2) gene in the E...
Topics
- Animals
- Blotting, Northern
- Blotting, Southern
- Cell Cycle
- Cell Division
- Chloramphenicol O-Acetyltransferase
- Genes, Dominant
- Genes, Tumor Suppressor
- Kidney Neoplasms
- Kinetics
- Mutation
- Phenotype
- Rats
- Rats, Mutant Strains
- Recombinant Proteins
- Repressor Proteins
- Transfection
- Tuberous Sclerosis