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Article

Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus.

Molecular carcinogenesis - 1 Feb 1996

Walker C, Ahn Y T, Everitt J, Yuan X

Abstract excerpt

Germline alterations of the human von Hippel-Lindau (VHL) tumor suppressor gene predispose to renal cell carcinoma and a constellation of other tumor types found in VHL disease. This gene is also mutated or deleted in a high proportion of sporadic nonpapillary renal cell carcinomas. In the Eker rat model, spontaneous renal cell carcinoma develops with a high frequency. We therefore investigated the role of this...

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Source

Identifiers

PMID: 8599582
DOI: 10.1002/(SICI)1098-2744(199602)15:2<154::AID-MC8>3.0.CO;2-J

Genes

VHL

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus.PMID 8599582Read ↗

Polymerase chain reaction-single-strand conformation polymorphism analysis for the VHL gene in chemically induced kidney tumors of rats using intron-derived primers.Semantic proximity Read ↗

Germ-line mutations in the von Hippel-Lindau tumor-suppressor gene are similar to somatic von Hippel-Lindau aberrations in sporadic renal cell carcinoma.Semantic proximity Read ↗

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Characterization of the VHL tumor suppressor gene product: localization, complex formation, and the effect of natural inactivating mutations.Semantic proximity Read ↗

Susceptibility to vascular neoplasms but no increased susceptibility to renal carcinogenesis in Vhl knockout mice.Semantic proximity Read ↗

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