Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus.

doi:10.1002/(SICI)1098-2744(199602)15:2<154::AID-MC8>3.0.CO;2-J

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Article

Renal cell carcinoma development in the rat independent of alterations at the VHL gene locus.

Molecular carcinogenesis - 1 Feb 1996

Walker C, Ahn Y T, Everitt J, Yuan X

Abstract excerpt

Germline alterations of the human von Hippel-Lindau (VHL) tumor suppressor gene predispose to renal cell carcinoma and a constellation of other tumor types found in VHL disease. This gene is also mutated or deleted in a high proportion of sporadic nonpapillary renal cell carcinomas. In the Eker r...

Topics

Animals
Animals, Newborn
Base Sequence
Blotting, Northern
Carcinoma, Renal Cell
Cell Line
DNA
Gene Expression
Genes, Tumor Suppressor
Humans
Kidney Neoplasms
Ligases
Mesothelin
Mesothelioma
Methylnitronitrosoguanidine
Mice
Molecular Sequence Data
Mutation

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