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Article

Interstitial chromosomal deletion of the tuberous sclerosis complex 2 locus is a signature for radiation-associated renal tumors in Eker rats.

Cancer science - 1 Mar 2020

Inoue Tatsuya, Kokubo Toshiaki, Daino Kazuhiro, Yanagihara Hiromi, Watanabe Fumiko, Tsuruoka Chizuru, Amasaki Yoshiko, Morioka Takamitsu, Homma-Takeda Shino, Kobayashi Toshiyuki, Hino Okio, Shimada Yoshiya, Kakinuma Shizuko

Abstract excerpt

Ionizing radiation can damage DNA and, therefore, is a risk factor for cancer. Eker rats, which carry a heterozygous germline mutation in the tumor-suppressor gene tuberous sclerosis complex 2 (Tsc2), are susceptible to radiation-induced renal carcinogenesis. However, the molecular mechanisms involved in Tsc2 inactivation are unclear. We subjected Fischer 344 × Eker (Long Evans Tsc2+/- ) F1 hybrid rats to...

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PMID: 31925975
DOI: 10.1111/cas.14307
PMCID: PMC7060461

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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