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Article

Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.

Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1993

Yeung R S, Buetow K H, Testa J R, Knudson A G

Abstract excerpt

Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC) results in multiple chromophobe cell tumors that resemble the human disease, and heterozygous carriers (RC/+) are highly susceptible to environmental agents (radiation and chemical carcinogens), making it a desirable model to study epithelial...

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Identifiers

PMID: 8103600
DOI: 10.1073/pnas.90.17.8038
PMCID: PMC47283

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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