Article
Susceptibility to renal carcinoma in the Eker rat involves a tumor suppressor gene on chromosome 10.
Proceedings of the National Academy of Sciences of the United States of America - 1 Sept 1993
Yeung R S, Buetow K H, Testa J R, Knudson A G
Abstract excerpt
Germ-line mutations of tumor suppressor genes confer strong predisposition to tumor formation. In the rat, a form of dominantly inherited renal carcinoma (RC) results in multiple chromophobe cell tumors that resemble the human disease, and heterozygous carriers (RC/+) are highly susceptible to en...
Topics
- Animals
- Chromosome Mapping
- Crosses, Genetic
- Female
- Fluorescent Dyes
- Genes, Tumor Suppressor
- Genetic Linkage
- Genetic Markers
- Genetic Predisposition to Disease
- In Situ Hybridization, Fluorescence
- Karyotyping
- Kidney Neoplasms
- Lod Score
- Male
- Phenotype
- Polymorphism, Restriction Fragment Length
- Rats
- Rats, Inbred BN