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Article

Genetic predisposition to transplacentally induced renal cell carcinomas in the Eker rat.

Cancer research - 15 Dec 1993

Hino O, Mitani H, Knudson A G

Abstract excerpt

N-Ethyl-N-nitrosourea-induced transplacental renal carcinogenesis in the rat results primarily in Wilms' tumors, apparently because primitive nephroblasts are the preferred target. Our question is whether N-ethyl-N-nitrosourea-induced mutations in the fetal kidney would increase the number of adult-type renal cell carcinomas in the Eker rat, which is heterozygous for a mutation that predisposes to renal cell...

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PMID: 8261394

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Genetic predisposition to transplacentally induced renal cell carcinomas in the Eker rat.PMID 8261394Read ↗

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Increased susceptibility to in vitro transformation of cells carrying the Eker tumor susceptibility mutation.Semantic proximity Read ↗

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Predisposition to renal carcinoma in the Eker rat is determined by germ-line mutation of the tuberous sclerosis 2 (TSC2) gene.Semantic proximity Read ↗

Molecular genetic basis of renal carcinogenesis in the Eker rat model of tuberous sclerosis (Tsc2).Semantic proximity Read ↗

Multistep renal carcinogenesis in the Eker (Tsc 2 gene mutant) rat model.Semantic proximity Read ↗

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Inheritance of susceptibility to induction of nephroblastomas in the Noble rat.Semantic proximity Read ↗

Allelic loss at the predisposing gene locus in spontaneous and chemically induced renal cell carcinomas in the Eker rat.Semantic proximity Read ↗

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