JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2.

doi:10.1073/pnas.90.20.9369

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Article

JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1993

Kameda T, Akahori A, Sonobe M H, Suzuki T, Endo T, Iba H

Abstract excerpt

Although a replication-competent retrovirus that carries junD has no transforming activity in chicken embryo fibroblasts, we have isolated mutant viruses that have spontaneously acquired transforming activity. The molecularly cloned junD genes of three such mutant viruses (T1, T2, and T3) were sh...

Topics

Amino Acid Sequence
Animals
Base Sequence
Cell Transformation, Neoplastic
Chick Embryo
Cloning, Molecular
DNA-Binding Proteins
Fos-Related Antigen-2
Gene Expression Regulation
Molecular Sequence Data
Mutation
Oncogenes
Proto-Oncogene Proteins c-fos

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Proto-Oncogene Proteins c-jun

Structure-Activity Relationship

Transcription Factors

Transcription, Genetic

Transcriptional Activation

Source

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Identifiers

PMID: 8415709
DOI: 10.1073/pnas.90.20.9369
PMCID: PMC47569

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8415709-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.