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Article

JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2.

Proceedings of the National Academy of Sciences of the United States of America - 15 Oct 1993

Kameda T, Akahori A, Sonobe M H, Suzuki T, Endo T, Iba H

Abstract excerpt

Although a replication-competent retrovirus that carries junD has no transforming activity in chicken embryo fibroblasts, we have isolated mutant viruses that have spontaneously acquired transforming activity. The molecularly cloned junD genes of three such mutant viruses (T1, T2, and T3) were shown to be responsible for the cellular transformation. DNA sequence analysis indicated that a specific polynucleotide...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 8415709
DOI: 10.1073/pnas.90.20.9369
PMCID: PMC47569

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JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2.PMID 8415709Read ↗

Unstable retrovirus mutants with acquired transforming activity: rapid changes in the number of repeats of a specific junD polynucleotide segment.Semantic proximity Read ↗

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.Semantic proximity Read ↗

Oncogenic transformation by Jun: role of transactivation and homodimerization.Semantic proximity Read ↗

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The oncogenicity of Jun.Semantic proximity Read ↗

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Chimeric c-Jun containing an heterologous homodimerization domain transforms primary chick embryo fibroblasts.Semantic proximity Read ↗

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