Article
Efficient induction of fibrosarcomas by v-jun requires mutations in the DNA binding region and the transactivation domain.
Oncogene - 1 Oct 1994
Morgan I M, Håvarstein L S, Wong W Y, Luu P, Vogt P K
Abstract excerpt
v-jun is the transforming gene of ASV 17, a retrovirus isolated from a spontaneous chicken fibrosarcoma. There are three mutations in the viral Jun protein (v-Jun) as compared to its cellular progenitor c-Jun: a deletion in the transactivation domain (called delta) and two amino acid substitutions in and near the DNA binding region. The effect of each of these mutations on fibrosarcoma development is described....
Topics
- Animals
- Chickens
- DNA-Binding Proteins
- Fibrosarcoma
- Genes, jun
- Mutation
- Oncogene Protein p65(gag-jun)
- Retroviridae
- Sequence Deletion
- Transcriptional Activation