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Article

The oncogenicity of Jun.

Leukemia - 1 Jan 1992

Vogt P K, Morgan I M, Håvarstein L, Su H, Hartl M, Schuur E

Abstract excerpt

A mutational analysis of the delta region of the Jun protein shows an inverse correlation between transforming and transactivation potential of the mutant proteins if both properties are measured in chicken embryo fibroblasts. The possibility that Jun acquires oncogenicity not by gain but by loss of function is also suggested by the down regulation of the differentiation control element MyoD by Jun and by the low...

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Source

Identifiers

PMID: 1602820

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The oncogenicity of Jun.PMID 1602820Read ↗

Oncogenic transformation by Jun: role of transactivation and homodimerization.Semantic proximity Read ↗

Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.Semantic proximity Read ↗

Jun, the oncoprotein.Semantic proximity Read ↗

Efficient induction of fibrosarcomas by v-jun requires mutations in the DNA binding region and the transactivation domain.Semantic proximity Read ↗

JunD mutants with spontaneously acquired transforming potential have enhanced transactivating activity in combination with Fra-2.Semantic proximity Read ↗

Both Jun and Fos contribute to transcription activation by the heterodimer.Semantic proximity Read ↗

Transformation suppressor activity of a Jun transcription factor lacking its activation domain.Semantic proximity Read ↗

Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: A converging transforming pathway for avian oncovirusesSemantic proximity Read ↗

An oncogenic mutation uncouples the v-Jun oncoprotein from positive regulation by the SAPK/JNK pathway in vivo.Semantic proximity Read ↗

Maf and Jun nuclear oncoproteins share downstream target genes for inducing cell transformation.Semantic proximity Read ↗

Cellular Transformation and Malignancy Induced by ras Require c-junSemantic proximity Read ↗

Transcription factor JunD, deprived of menin, switches from growth suppressor to growth promoterSemantic proximity Read ↗

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