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Article

Unstable retrovirus mutants with acquired transforming activity: rapid changes in the number of repeats of a specific junD polynucleotide segment.

Nucleic acids research - 1 Nov 1998

Ito T, Kabuyama Y, Okazaki S, Kameda T, Murakami M, Iba H

Abstract excerpt

We have previously reported that the non-transforming jun D (wild type) gene can acquire transforming activity through spontaneous mutations when it is replicated through avian replication-competent retrovirus vectors in chicken embryo fibroblasts. In two of these spontaneous mutants, T1 and T2, which were isolated from proviral DNA in the same transformed cell clone, a specific 48 bp polynucleotide segment of...

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Identifiers

PMID: 9776746
DOI: 10.1093/nar/26.21.4868
PMCID: PMC147946

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