Article
Unstable retrovirus mutants with acquired transforming activity: rapid changes in the number of repeats of a specific junD polynucleotide segment.
Nucleic acids research - 1 Nov 1998
Ito T, Kabuyama Y, Okazaki S, Kameda T, Murakami M, Iba H
Abstract excerpt
We have previously reported that the non-transforming jun D (wild type) gene can acquire transforming activity through spontaneous mutations when it is replicated through avian replication-competent retrovirus vectors in chicken embryo fibroblasts. In two of these spontaneous mutants, T1 and T2,...
Topics
- Animals
- Avian Sarcoma Viruses
- Base Sequence
- Cells, Cultured
- Chick Embryo
- DNA Replication
- DNA, Viral
- Gene Amplification
- Genes, jun
- Genetic Vectors
- Mice
- Minisatellite Repeats
- Mutation
- Nucleic Acid Conformation
- Plasmids
- Proviruses
- Repetitive Sequences, Nucleic Acid
- Transfection