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Article

Oncogenic transformation by Jun: role of transactivation and homodimerization.

Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research - 1 Dec 1992

Hartl M, Vogt P K

Abstract excerpt

Jun/JunD and Jun/GCN4 chimeras transform chicken embryo fibroblasts and activate the collagenase promoter in these same cells. Individual constructs differ widely in the two activities, and there is no correlation between transformation and transactivation. These results suggest that oncogenic transformation by Jun is not caused merely by an upregulation of AP-1 activity. Jun constructs with a modified...

Topics

Animals
Biopolymers
Cell Transformation, Neoplastic
Chick Embryo
Fibroblasts
Genetic Vectors
Mutation
Protein Structure, Tertiary
Proto-Oncogene Proteins c-jun
Recombinant Proteins
Transcription, Genetic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Transcriptional Activation

Source

Identifiers

PMID: 1472470

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1472470-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Oncogenic transformation by Jun: role of transactivation and homodimerization.PMID 1472470Read ↗

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Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.Semantic proximity Read ↗

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