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Article

Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: A converging transforming pathway for avian oncoviruses

3 Oct 2005

Abstract excerpt

Marek's disease virus (MDV) is a highly pathogenic and oncogenic herpesvirus of chickens. MDV encodes a basic leucine zipper (bZIP) protein, Meq (MDV EcoQ). The bZIP domain of Meq shares homology with Jun/Fos, whereas the transactivation/repressor domain is entirely different. Increasing evidence suggests that Meq is the oncoprotein of MDV. Direct evidence that Meq transforms chicken cells and the underlying...

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Identifiers

PMID: 16203997
DOI: 10.1073/pnas.0506849102

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Marek's disease virus Meq transforms chicken cells via the v-Jun transcriptional cascade: A converging transforming pathway for avian oncovirusesPMID 16203997Read ↗

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Transforming Potential of the Herpesvirus Oncoprotein MEQ: Morphological Transformation, Serum-Independent Growth, and Inhibition of ApoptosisSemantic proximity Read ↗

Interaction of MEQ protein and C-terminal-binding protein is critical for induction of lymphomas by Marek's disease virus.Semantic proximity Read ↗

Characterization of the Chromosomal Binding Sites andDimerization Partners of the Viral Oncoprotein Meq in Marek'sDisease Virus-Transformed TCellsSemantic proximity Read ↗

Homodimerization of Marek's Disease Virus-Encoded Meq Protein Is Not Sufficient for Transformation of Lymphocytes in ChickensSemantic proximity Read ↗

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Marek disease virus encodes a basic-leucine zipper gene resembling the fos/jun oncogenes that is highly expressed in lymphoblastoid tumors.Semantic proximity Read ↗

Maf and Jun nuclear oncoproteins share downstream target genes for inducing cell transformation.Semantic proximity Read ↗

The molecular interactions of the Marek's disease virus-encoded oncoprotein MeqSemantic proximity Read ↗

Both homo and heterodimers of Marek's disease virus encoded Meq protein contribute to transformation of lymphocytes in chickens.Semantic proximity Read ↗

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