Article
Efficient transformation of chicken embryo fibroblasts by c-Jun requires structural modification in coding and noncoding sequences.
Genes & development - 1 Oct 1990
Bos T J, Monteclaro F S, Mitsunobu F, Ball A R, Chang C H, Nishimura T, Vogt P K
Abstract excerpt
To assess the transforming capability of the c-Jun protein, we introduced the chicken c-jun proto-oncogene into a replication competent avian retroviral expression vector (RCAS). Viral Jun efficiently transformed chicken embryo fibroblasts (CEFs) when expressed from this vector. Overexpression of...
Topics
- Amino Acid Sequence
- Animals
- Cell Transformation, Neoplastic
- Chick Embryo
- Chromosome Deletion
- DNA-Binding Proteins
- Fibroblasts
- Genetic Code
- Genetic Vectors
- Molecular Sequence Data
- Mutation
- Proto-Oncogene Proteins
- Proto-Oncogene Proteins c-jun
- Transcription Factors
- Transfection