Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside).

doi:10.1073/pnas.0407297101

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Article

Reversion of the Jun-induced oncogenic phenotype by enhanced synthesis of sialosyllactosylceramide (GM3 ganglioside).

Proceedings of the National Academy of Sciences of the United States of America - 16 Nov 2004

Miura Yutaka, Kainuma Mami, Jiang Hao, Velasco Hershey, Vogt Peter K, Hakomori Senitiroh

Abstract excerpt

In the mouse fibroblast cell line C3H 10T1/2 and the chicken fibroblast cell line DF1, the ganglioside GM3 is the major glycosphingolipid component of the plasma membrane. Expression of the viral oncoprotein Jun (v-Jun) induces transformed cell clones with greatly reduced levels of GM3 and GM3 synthase (lactosylceramide alpha2,3-sialyltransferase) mRNA in both 10T1/2 and DF1 cell cultures. Compared with...

Topics

Animals
Antigens, CD
Base Sequence
Cell Adhesion
Cell Division
Cell Line, Transformed
Chick Embryo
Down-Regulation
G(M3) Ganglioside
Genes, jun
Integrin alpha5beta1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Membrane Glycoproteins

Mice

Molecular Sequence Data

Oncogene Protein p65(gag-jun)

Phenotype

RNA, Messenger

Sialyltransferases

Source

Open in PubMed Open full text

Identifiers

PMID: 15534203
DOI: 10.1073/pnas.0407297101
PMCID: PMC528971

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026.

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