Article
Infrequent alterations of the APC and MCC genes in gastric cancers from British patients.
British journal of cancer - 1 Oct 1996
Sud R, Talbot I C, Delhanty J D
Abstract excerpt
We examined 26 gastric carcinomas from British patients for mutations of the APC gene using a single-strand conformation polymorphism (SSCP) and heteroduplex assay in conjunction with the protein truncation test (PTT). In addition, we performed loss of heterozygosity (LOH) analysis of the APC and MCC genes. We detected an inactivating somatic mutation in one gastric tumour. LOH of APC was observed in one of 12...
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