MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.

Article

MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.

Oncogene - 1 Oct 1991

Ashton-Rickardt P G, Wyllie A H, Bird C C, Dunlop M G, Steel C M, Morris R G, Piris J, Romanowski P, Wood R, White R

Abstract excerpt

MCC is a gene located within human chromosome band 5q.21 that shows somatically acquired mutations in colorectal cancer, and may be identical to the gene responsible for inheritance of familial adenomatous polyposis. Here we demonstrate that alleles contiguous with or within MCC are deleted in a...

Topics

Adenomatous Polyposis Coli
Alleles
Chromosome Deletion
Chromosome Mapping
Chromosomes, Human, Pair 5
Colorectal Neoplasms
Humans
Lung Neoplasms

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