Article
MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.
Oncogene - 1 Oct 1991
Ashton-Rickardt P G, Wyllie A H, Bird C C, Dunlop M G, Steel C M, Morris R G, Piris J, Romanowski P, Wood R, White R
Abstract excerpt
MCC is a gene located within human chromosome band 5q.21 that shows somatically acquired mutations in colorectal cancer, and may be identical to the gene responsible for inheritance of familial adenomatous polyposis. Here we demonstrate that alleles contiguous with or within MCC are deleted in a high proportion of sporadic colorectal carcinomas. Of 106 carcinomas that were informative concurrently at...
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