Article
Loss of heterozygosity at 5q21 in non-small cell lung cancer: a frequent event but without evidence of apc mutation.
The Journal of pathology - 1 Sept 1996
Cooper C A, Bubb V J, Smithson N, Carter R L, Gledhill S, Lamb D, Wyllie A H, Carey F A
Abstract excerpt
Four genetic polymorphisms in the APC and MCC genes at chromosome 5q21 were analysed for loss of heterozygosity (LOH) in 97 primary squamous carcinomas and adenocarcinomas of the lung. LOH was identified in at least two polymorphic loci in 41 percent of informative cases. There was no significant...
Topics
- Adenocarcinoma
- Base Sequence
- Carcinoma, Non-Small-Cell Lung
- Carcinoma, Squamous Cell
- Chromosome Deletion
- Chromosomes, Human, Pair 5
- Genes, APC
- Genes, MCC
- Humans
- Lung Neoplasms
- Molecular Sequence Data
- Mutation
- Polymorphism, Single-Stranded Conformational