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Article

Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis.

Gastroenterology - 1 Jun 1994

Rhyu M G, Park W S, Jung Y J, Choi S W, Meltzer S J

Abstract excerpt

BACKGROUND/AIMS: Frequent allelic deletion affecting the mutated in colon cancer/adenomatous polyposis coli (MCC/APC) and p53 tumor suppressor gene loci has been reported in human cancers. However, simultaneous correlative analyses of these two abnormalities or their timing in gastric tumorigenes...

Topics

Adenomatous Polyposis Coli
Alleles
Base Sequence
DNA Mutational Analysis
Gene Deletion
Heterozygote
Humans
Molecular Probes
Molecular Sequence Data
Stomach Neoplasms
Time Factors
Tumor Suppressor Protein p53

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 8194705
DOI: 10.1016/0016-5085(94)90414-6

Genes

MCC
APC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8194705-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis.PMID 8194705Read ↗

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

The sequential accumulation of genetic alterations characteristic of the colorectal adenoma-carcinoma sequence does not occur between gastric adenoma and adenocarcinoma.Semantic proximity Read ↗

Genetic and epigenetic changes in the APC gene in sporadic colorectal carcinoma with synchronous adenoma.Semantic proximity Read ↗

Loss of heterozygosity in human aberrant crypt foci (ACF), a putative precursor of colon cancer.Semantic proximity Read ↗

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.Semantic proximity Read ↗

Low frequency and late occurrence of p53 and dcc aberrations in colorectal tumours.Semantic proximity Read ↗

Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.Semantic proximity Read ↗

Monoallelic silencing and haploinsufficiency in early murine intestinal neoplasms.Semantic proximity Read ↗

Loss of heterozygosity at APC and MCC genes of oral cancer and leukoplakia tissues from Indian tobacco chewers.Semantic proximity Read ↗

Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.Semantic proximity Read ↗

Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer.Semantic proximity Read ↗

Promoter methylation of the mutated in colorectal cancer gene is a frequent early event in colorectal cancer.Semantic proximity Read ↗

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