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Article

Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 1994

Medeiros A C, Nagai M A, Neto M M, Brentani R R

Abstract excerpt

Tumor suppressor genes APC and MCC were identified recently, and their chromosomal location was ascribed to chromosome 5q21. Mutations in the APC gene give rise to familial adenomatous polyposis and occur in many perhaps even the majority, of sporadic colon cancers. Loss of heterozygosity has been described in other human tumors such as lung and esophageal cancers. Here we show loss of heterozygosity (LOH) in 87...

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Source

Identifiers

PMID: 8061582

Genes

APC
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.PMID 8061582Read ↗

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.Semantic proximity Read ↗

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

Loss of heterozygosity at 5q21 in non-small cell lung cancer: a frequent event but without evidence of apc mutation.Semantic proximity Read ↗

Allele loss from 5q21 (APC/MCC) and 18q21 (DCC) and DCC mRNA expression in breast cancer.Semantic proximity Read ↗

MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.Semantic proximity Read ↗

Allelic deletions of MCC/APC and p53 are frequent late events in human gastric carcinogenesis.Semantic proximity Read ↗

Somatic mutations of the APC gene in colorectal tumors: mutation cluster region in the APC gene.Semantic proximity Read ↗

Aberrations of tumor-suppressor genes (p53, apc, mcc and Rb) in esophageal squamous-cell carcinoma.Semantic proximity Read ↗

Loss of heterozygosity of MCC is not associated with mutation of the retained allele in sporadic colorectal cancer.Semantic proximity Read ↗

Somatic mutations of the APC gene in sporadic hepatoblastomas.Semantic proximity Read ↗

Loss of heterozygosity at APC and MCC genes of oral cancer and leukoplakia tissues from Indian tobacco chewers.Semantic proximity Read ↗

Copy number of the Adenomatous Polyposis Coli gene is not always neutral in sporadic colorectal cancers with loss of heterozygosity for the gene.Semantic proximity Read ↗

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