Article
Loss of heterozygosity affecting the APC and MCC genetic loci in patients with primary breast carcinomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Jun 1994
Medeiros A C, Nagai M A, Neto M M, Brentani R R
Abstract excerpt
Tumor suppressor genes APC and MCC were identified recently, and their chromosomal location was ascribed to chromosome 5q21. Mutations in the APC gene give rise to familial adenomatous polyposis and occur in many perhaps even the majority, of sporadic colon cancers. Loss of heterozygosity has bee...
Topics
- Base Sequence
- Breast Neoplasms
- Chromosome Deletion
- DNA, Neoplasm
- Exons
- Female
- Genes, APC
- Genes, MCC
- Heterozygote
- Humans
- Molecular Sequence Data
- Mutation
- Polymerase Chain Reaction