Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Evidence for a common molecular pathogenesis in colorectal, gastric, and pancreatic cancer.

Genes, chromosomes & cancer - 1 Nov 1991

Neuman W L, Wasylyshyn M L, Jacoby R, Erroi F, Angriman I, Montag A, Brasitus T, Michelassi F, Westbrook C A

Abstract excerpt

We examined tissue extracted from 19 gastric, 7 pancreatic, and 23 colorectal carcinoma specimens to determine the comparative incidence of allele loss on chromosomes 5, 17, and 18 and that of KRAS2 point mutations. Chromosome 5 allele loss occurred at the same frequency in all three gastrointestinal tumors (approximately 30%), whereas chromosome 17 and 18 allele losses were seen at a significantly lower...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Base Sequence
Share to Chromosome Deletion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA Mutational Analysis

Share to DNA, Neoplasm

Share to Genetic Predisposition to Disease

Share to Molecular Sequence Data

Share to Polymerase Chain Reaction

Source

Identifiers

PMID: 1663781
DOI: 10.1002/gcc.2870030609

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Evidence for a common molecular pathogenesis in colorectal, gastric, and pancreatic cancer.PMID 1663781Read ↗

Genetic alterations of the transforming growth factor beta receptor genes in pancreatic and biliary adenocarcinomas.Semantic proximity Read ↗

Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.Semantic proximity Read ↗

Frequency and spectrum of mutations at codons 12 and 13 of the c-K-ras gene in human tumors.Semantic proximity Read ↗

Adenomatous polyposis coli gene involvement in ileal enterochromaffin cell neuroendocrine neoplasms.Semantic proximity Read ↗

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

Occurrence of Ki-ras and p53 mutations in primary colorectal tumors.Semantic proximity Read ↗

p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis.Semantic proximity Read ↗

Clinicopathologic significance of the K-ras gene codon 12 point mutation in stomach cancer. An analysis of 140 casesSemantic proximity Read ↗

Chromosomal changes in colorectal adenomas: relationship to gene mutations and potential for clinical utility.Semantic proximity Read ↗

Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas.Semantic proximity Read ↗

p53 mutations are common in pancreatic cancer and are absent in chronic pancreatitis.Semantic proximity Read ↗

Two novel mutations in exons 5 and 15 of the adenomatous polyposis coli (APC) gene.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.