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Article

Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas.

Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc - 1 Oct 2000

Choi Y W, Heath E I, Heitmiller R, Forastiere A A, Wu T T

Abstract excerpt

Beta-catenin plays important roles in both intercellular adhesion and signal transduction. Mutations in the beta-catenin or adenomatous polyposis coli (APC) gene can alter the degradation of beta-catenin and cause aberrant accumulation of beta-catenin result in increased transcription of target genes. The dysregulated APC/beta-catenin pathway has been recently discovered as an important mechanism of tumorigenesis...

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Identifiers

PMID: 11048797
DOI: 10.1038/modpathol.3880194

Genes

APC

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Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Mutations in beta-catenin and APC genes are uncommon in esophageal and esophagogastric junction adenocarcinomas.PMID 11048797Read ↗

APC gene mutations in the mutation cluster region are rare in esophageal cancers.Semantic proximity Read ↗

Genetic alterations involving exon 3 of the beta-catenin gene do not play a role in adenocarcinomas of the esophagus.Semantic proximity Read ↗

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.Semantic proximity Read ↗

Aberrant nuclear localization of β-catenin without genetic alterations in β-catenin or Axin genes in esophageal cancerSemantic proximity Read ↗

Lack of mutations of the adenomatous polyposis coli gene in oesophageal and gastric carcinomas.Semantic proximity Read ↗

Accumulation of beta-catenin protein and mutations in exon 3 of beta-catenin gene in gastrointestinal carcinoid tumor.Semantic proximity Read ↗

Nuclear translocation of beta-catenin protein but absence of beta-catenin and APC mutation in gastrointestinal carcinoid tumor.Semantic proximity Read ↗

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

Altered expression and mutation of beta-catenin gene in gastric carcinomas and cell lines.Semantic proximity Read ↗

Analysis of beta-catenin gene mutations in pancreatic tumors.Semantic proximity Read ↗

Expression of beta-catenin and E-cadherin in the adenoma-carcinoma sequence of the stomach.Semantic proximity Read ↗

Sporadic fundic gland polyps with epithelial dysplasia : evidence for preferential targeting for mutations in the adenomatous polyposis coli gene.Semantic proximity Read ↗

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