Article
APC gene mutations in the mutation cluster region are rare in esophageal cancers.
Gastroenterology - 1 Dec 1994
Powell S M, Papadopoulos N, Kinzler K W, Smolinski K N, Meltzer S J
Abstract excerpt
BACKGROUND/AIMS: The molecular pathogenesis of esophageal cancers is not completely understood. Frequent allelic losses occur on chromosome 5q, suggesting the presence of a tumor-suppressor gene that is important in esophageal tumorigenesis. Because the APC gene is located on chromosome 5q, we sought to determine its involvement as a candidate tumor-suppressor gene in esophageal carcinogenesis. METHODS:...
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