APC gene mutations in the mutation cluster region are rare in esophageal cancers.

doi:10.1016/0016-5085(94)90818-4

Back to search

Article

APC gene mutations in the mutation cluster region are rare in esophageal cancers.

Gastroenterology - 1 Dec 1994

Powell S M, Papadopoulos N, Kinzler K W, Smolinski K N, Meltzer S J

Abstract excerpt

BACKGROUND/AIMS: The molecular pathogenesis of esophageal cancers is not completely understood. Frequent allelic losses occur on chromosome 5q, suggesting the presence of a tumor-suppressor gene that is important in esophageal tumorigenesis. Because the APC gene is located on chromosome 5q, we so...

Topics

Adenocarcinoma
Base Sequence
Carcinoma, Squamous Cell
Chromosomes, Human, Pair 5
DNA Mutational Analysis
Esophageal Neoplasms
Genes, APC
Humans
Molecular Sequence Data
Multigene Family
Mutation
Polymorphism, Single-Stranded Conformational

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.