Article
Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.
Proceedings of the National Academy of Sciences of the United States of America - 15 Apr 1992
Boynton R F, Blount P L, Yin J, Brown V L, Huang Y, Tong Y, McDaniel T, Newkirk C, Resau J H, Raskind W H, Haggitt R C, Reid B J, Meltzer S J
Abstract excerpt
The tumor suppressor gene APC was recently identified, and the cDNA was cloned from chromosome 5q21. Point mutations affecting APC are seen in the hereditary syndrome familial adenomatous polyposis, and point mutations in APC and a closely linked gene, MCC, as well as loss of heterozygosity invol...
Topics
- Adenocarcinoma
- Base Sequence
- Carcinoma, Squamous Cell
- Chromosome Deletion
- Chromosomes, Human, Pair 5
- Cloning, Molecular
- DNA, Neoplasm
- Esophageal Neoplasms
- Exons
- Gastric Mucosa
- Genes
- Genes, Tumor Suppressor
- Genetic Linkage