Article
Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.
Science (New York, N.Y.) - 9 Aug 1991
Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P
Abstract excerpt
Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), and contribute to tumor development in patients with noninherited forms of colorectal cancer. Two genes on 5q21 that are ti...
Topics
- Adenomatous Polyposis Coli
- Amino Acid Sequence
- Base Sequence
- Chromosome Mapping
- Chromosomes, Human, Pair 5
- Codon
- Colonic Neoplasms
- DNA, Neoplasm
- Genetic Linkage
- Genetic Variation
- Humans
- Molecular Sequence Data
- Mutation
- Oligonucleotide Probes
- Polymerase Chain Reaction
- Rectal Neoplasms