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Article

Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.

Science (New York, N.Y.) - 9 Aug 1991

Nishisho I, Nakamura Y, Miyoshi Y, Miki Y, Ando H, Horii A, Koyama K, Utsunomiya J, Baba S, Hedge P

Abstract excerpt

Previous studies suggested that one or more genes on chromosome 5q21 are responsible for the inheritance of familial adenomatous polyposis (FAP) and Gardner's syndrome (GS), and contribute to tumor development in patients with noninherited forms of colorectal cancer. Two genes on 5q21 that are tightly linked to FAP (MCC and APC) were found to be somatically altered in tumors from sporadic colorectal cancer...

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Source

Identifiers

PMID: 1651563
DOI: 10.1126/science.1651563

Genes

FAP
APC
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

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Mutations of chromosome 5q21 genes in FAP and colorectal cancer patients.PMID 1651563Read ↗

Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.Semantic proximity Read ↗

Cell and molecular biology of gastrointestinal tract cancer.Semantic proximity Read ↗

Identification of FAP Locus Genes from Chromosome 5q21Semantic proximity Read ↗

Mutations of the adenomatous polyposis coli gene in familial polyposis coli patients and sporadic colorectal tumors.Semantic proximity Read ↗

Molecular nature of chromosome 5q loss in colorectal tumors and desmoids from patients with familial adenomatous polyposis.Semantic proximity Read ↗

Somatic mutations of the adenomatous polyposis coli gene in gastroduodenal tumors from patients with familial adenomatous polyposis.Semantic proximity Read ↗

[Identification of a colorectal tumor mutated gene on chromosome 5q21: a further step in the clarification of genetic relations in the pathogenesis of colorectal neoplasms].Semantic proximity Read ↗

Genetic characterization of the APC locus involved in familial adenomatous polyposis.Semantic proximity Read ↗

Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers.Semantic proximity Read ↗

Loss of heterozygosity involving the APC and MCC genetic loci occurs in the majority of human esophageal cancers.Semantic proximity Read ↗

MCC, a candidate familial polyposis gene in 5q.21, shows frequent allele loss in colorectal and lung cancer.Semantic proximity Read ↗

Abnormalities affecting the APC and MCC tumour suppressor gene loci on chromosome 5q occur frequently in gastric cancer but not in pancreatic cancer.Semantic proximity Read ↗

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