Article
Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.
The Tohoku journal of experimental medicine - 1 Oct 1992
Nakamura Y, Nishisho I, Kinzler K W, Vogelstein B, Miyoshi Y, Miki Y, Ando H, Horii A
Abstract excerpt
We have isolated several genes on chromosome 5q21 region tightly linked to hereditary familial polyposis coli (FAP) and Gardner's syndrome (GS). Two of these genes (MCC and APC) were found to be somatically altered by point mutation, deletion or insertion in tumors of sporadic colorectal cancer p...
Topics
- Adenomatous Polyposis Coli
- Base Sequence
- Chromosomes, Human, Pair 5
- Cloning, Molecular
- Colorectal Neoplasms
- DNA
- DNA, Neoplasm
- Genes, APC
- Humans
- Molecular Sequence Data
- Mutation