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Article

Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.

The Tohoku journal of experimental medicine - 1 Oct 1992

Nakamura Y, Nishisho I, Kinzler K W, Vogelstein B, Miyoshi Y, Miki Y, Ando H, Horii A

Abstract excerpt

We have isolated several genes on chromosome 5q21 region tightly linked to hereditary familial polyposis coli (FAP) and Gardner's syndrome (GS). Two of these genes (MCC and APC) were found to be somatically altered by point mutation, deletion or insertion in tumors of sporadic colorectal cancer patients. One (APC) of them was also found mutations in the germ line of both APC and GS patients. The identification of...

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Source

Identifiers

PMID: 1339098
DOI: 10.1620/tjem.168.141

Genes

APC
FAP
MCC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Mutations of the APC (adenomatous polyposis coli) gene in FAP (familial polyposis coli) patients and in sporadic colorectal tumors.PMID 1339098Read ↗

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