Article
Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.
Gastroenterology - 1 Feb 1995
Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H
Abstract excerpt
BACKGROUND/AIMS: The relationship of aberrant crypt foci (ACF) to colorectal carcinogenesis is still controversial. Histological examination and analyses of K-ras mutations and p53 gene expression were performed to characterize ACF. METHODS: ACF were identified microscopically in grossly normal colorectal mucosa. The ACF were separated into two pieces, one for histological and immunohistochemical examinations and...
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