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Article

Frequent and characteristic K-ras activation and absence of p53 protein accumulation in aberrant crypt foci of the colon.

Gastroenterology - 1 Feb 1995

Yamashita N, Minamoto T, Ochiai A, Onda M, Esumi H

Abstract excerpt

BACKGROUND/AIMS: The relationship of aberrant crypt foci (ACF) to colorectal carcinogenesis is still controversial. Histological examination and analyses of K-ras mutations and p53 gene expression were performed to characterize ACF. METHODS: ACF were identified microscopically in grossly normal c...

Topics

Adult
Aged
Aged, 80 and over
Carcinoma
Colorectal Neoplasms
Female
Genes, ras
Humans
Male
Middle Aged
Mutation
Precancerous Conditions
Tumor Suppressor Protein p53

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Identifiers

PMID: 7835585
DOI: 10.1016/0016-5085(95)90071-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-7835585-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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