K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.

doi:10.1016/s0304-3835(97)04709-5

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Article

K-ras and p53 mutations in aberrant crypt foci and colonic tumors from colon cancer patients.

Cancer letters - 1 May 1997

Shivapurkar N, Huang L, Ruggeri B, Swalsky P A, Bakker A, Finkelstein S, Frost A, Silverberg S

Abstract excerpt

Aberrant crypt foci (ACF) are microscopic lesions which can be detected, after methylene blue staining, in the overtly normal looking colonic mucosa of cancer patients. ACF have been postulated to be precursor lesions which develop into colorectal cancer. Mutations of K-ras and p53 are two import...

Topics

Adenoma
Carcinoma
Colonic Neoplasms
Genes, p53
Genes, ras
Humans
Mutation
Polymerase Chain Reaction
Polymorphism, Single-Stranded Conformational
Precancerous Conditions

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