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Article

Constitutively active mutants of the alpha 2-adrenergic receptor.

The Journal of biological chemistry - 5 Aug 1993

Ren Q, Kurose H, Lefkowitz R J, Cotecchia S

Abstract excerpt

We have mutated a single residue, Thr373 [corrected], in the C-terminal portion of the third intracellular loop of the alpha 2C10-adrenergic receptor into five different amino acids. In analogy with the effect of similar mutations in the alpha 1B- and beta 2-adrenergic receptors, these substitutions resulted in two major biochemical modifications: 1) increased constitutive activity of the alpha 2-adrenergic...

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PMID: 8393865

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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